Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures
Emilia Komulainen, Jack Badman, Stephanie A. Rey, Stuart L. Rulten, Limei Ju, Kate Fennell, Peter J. McKinnon, Kevin Staras, Keith W. Caldecott
This study shows that aberrant PARP1 activity at unrepaired DNA breaks causes deregulated presynaptic calcium signaling and lethal seizures in Xrcc1-defective mice, suggesting PARP inhibition as a therapeutic strategy.
bioRxiv · May 15, 2020 · PreprintNeuroscience