NeurosciencebioRxivPreprint
Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures
Emilia Komulainen, Jack Badman, Stephanie A. Rey…·Keith W. Caldecott
This study shows that aberrant PARP1 activity at unrepaired DNA breaks causes deregulated presynaptic calcium signaling and lethal seizures in Xrcc1-defective mice, suggesting PARP inhibition as a therapeutic strategy.
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