Kevin Staras

The paper shows that HCN channel dysfunction is linked to tauopathies, with altered synaptic structure and function in Alzheimer's and Tau35 mouse models.

The paper develops a method to map synaptic activity in vivo using FIBSEM and machine learning, revealing distribution patterns of vesicles in synapses of awake mice.

This study shows that aberrant PARP1 activity at unrepaired DNA breaks causes deregulated presynaptic calcium signaling and lethal seizures in Xrcc1-defective mice, suggesting PARP inhibition as a therapeutic strategy.

This paper introduces a new two-photon microscopy technique that expands the 3D field of view while maintaining single-cell resolution, enabling more comprehensive neuronal activity imaging in multiple organisms.

The paper uses optical reporters to show that Aβ42 oligomers disrupt the endo-lysosomal pathway by impairing protein uptake and causing lysosomal accumulation.

The paper identifies a central neural circuit in Lymnaea that encodes food value based on hunger state, using dopaminergic interneurons to drive behavioral shifts between ingestion and egestion.