This paper presents a computational pipeline for measuring retinal capillary blood flow using adaptive optics line confocal ophthalmoscopy, achieving accurate velocity measurements and improved motion correction.

bioRxiv · Sep 23, 2026 · PreprintBioengineering

Trans-eQTLs reveal the architecture of human gene regulatory networks

Robert Warmerdam, Harm-Jan Westra, Adriaan van der Graaf, Marc Jan Bonder, Patrick Deelen, Tijs van Lieshout, Anke Jannie Landman, Mihkel Jesse, Benjamin J. Strober, Toni A. Boltz, Sandra Lapinska, Sini Nagpal, Manke Xie, Darwin Tay, Holger Kirsten, , Habibul Ahsan

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

medRxiv · Feb 5, 2026 · PreprintGenetic & Genomic Medicine

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications

Suzuki Ken, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kim Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Nigel W. Rayner, Ozvan Bocher, S. V. Arruda Ana Luiza de, Kyuto Sonehara, Shinichi Namba, Simon S. K. Lee, Michael H. Preuss, , H. Janaka de Silva

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

Yearbook of pediatric endocrinology · Sep 8, 2023Peer-reviewedGenetic & Genomic Medicine

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan, Cassandra Nichole Spracklen, Weihua Zhang, Maggie C.Y. Ng, Lauren E. Petty, Hidetoshi Kitajima, Grace Z. Yu, Sina Rüeger, Leo Speidel, Young Jin Kim, Momoko Horikoshi, Josep Maria Mercader, Daniel Taliun, Sanghoon Moon, Soo‐Heon Kwak, , Mary Cushman

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

Discovery Research Portal (University of Dundee) · Jan 1, 2022Peer-reviewedGenetic & Genomic Medicine