This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

Discovery Research Portal (University of Dundee) · Jan 1, 2022Peer-reviewedGenetic & Genomic Medicine

Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes

Jun Hosoe, Suzuki Ken, Fuyuki Miya, Takashi Kato, Tatsuhiko Tsunoda, Yukinori Okada, Momoko Horikoshi, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki

The paper reports in silico structural analysis of ethnic-specific PAX4 variants associated with type 2 diabetes in a Japanese population.

Human Genome Variation · Jul 5, 2021Peer-reviewedGenetics

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

Ji Chen, Cassandra Nichole Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’an Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud Boutin, Reedik Mägi, Johannes Waage, Achilleas Pitsillides, Ruifang Li‐Gao, , Michael H Preuss

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

bioRxiv · Jul 23, 2020 · PreprintGenetics

Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population

Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi M. Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, , Keitaro Matsuo

Nature Communications · Jun 24, 2020Peer-reviewedGenetics

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew‐Kee Low, Yukinori Okada, Chikashi C. Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, , Yoichiro Kamatani

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

Nature Genetics · Jun 8, 2020Peer-reviewedGenetics

Identification of type 2 diabetes loci in 433,540 East Asian individuals

Cassandra Nichole Spracklen, Momoko Horikoshi, Young Jin Kim, Kuang Lin, Fiona Bragg, Sanghoon Moon, Suzuki Ken, Claudia H.T. Tam, Yasuharu Tabara, Soo‐Heon Kwak, Fumihiko Takeuchi, Jirong Long, Victor Lim, Jin Fang Chai, Chien-Hsiun Chen, , Kyong Soo Park

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.

Nature · May 6, 2020Peer-reviewedGenetics

Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease

Satoshi Koyama, Kaoru Ito, Chikashi C. Terao, Masato Akiyama, Momoko Horikoshi, Yukihide Momozawa, Hiroshi Matsunaga, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Atsushi Takahashi, Seitaro Nomura, Hiroyuki Morita, Hiroshi Akazawa, Changhoon Kim, , Issei Komuro

This study identifies novel genetic loci for coronary artery disease in Japanese and transethnic populations and develops a polygenic risk score that outperforms population-specific scores.

bioRxiv · Nov 16, 2019 · PreprintGenetics

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bačelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, Nigel William Rayner, , Cæcilie Trier

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

Nature Genetics · May 1, 2019Peer-reviewedGenetics

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Momoko Horikoshi, Felix R. Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A. Toro, Sergio R. Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K. Ong, John R. B. Perry

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.

Nature Communications · May 11, 2018Peer-reviewedGenetics

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

Robin N. Beaumont, Nicole M. Warrington, Alana Cavadino, Jessica Tyrrell, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca Claire Richmond, Lavinia Paternoster, Jonathan P. Bradfield, Eskil Kreiner‐Møller, Ville Huikari, Sarah Metrustry, Kathryn L. Lunetta, , Rachel M. Freathy

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

Human Molecular Genetics · Jan 2, 2018Peer-reviewedGenetics