Leo Speidel

This study uses joint genealogies of dogs, wolves, and coyotes to uncover evolutionary forces shaping the dog genome, identifying mutation-rate pulses, selection signatures, and introgression events.

This study analyzes ancient genomes from Roman and early medieval Britain to uncover population history, ancestry shifts, and selection patterns shaping modern genetic diversity.

This paper introduces GhostBuster, a method to detect unsampled admixture events in human history using genome-wide genealogies, revealing multiple back-to-Africa migrations and deep ancestral lineages.

This study sequenced ancient and modern genomes from the Ryukyu Archipelago to show genetic differentiation between Ryukyu Jomon and Hondo populations, with admixture occurring around 1,000 YBP.

mrpast infers complex demographic histories from whole-genome genealogies, accurately recovering parameters like migration rates and population sizes in various models.

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

This study uses high-resolution genomic ancestry analysis to reveal mobility patterns in early medieval Europe using ancient DNA.

The paper identifies 995 genes with shared genetic links to age-related diseases using GWAS data and presents them in a web tool for drug target prioritization.

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

This paper introduces methods to infer population histories using ancient genomes and genealogies, revealing insights into population dynamics and mutation rates in ancient populations.

This paper introduces a method to estimate polygenic adaptation using whole-genome genealogies and GWAS data, finding evidence of directional selection on multiple human traits and correlated responses.

This paper introduces a method to estimate genome-wide genealogies for thousands of samples, revealing new insights into human evolutionary history and selection.