Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy
Bin Wei Yao, Xueting Ye, Qian Kong, Wendong Chen, Wentao Li, Chun Feng, An He, Guoqiang Li, Lan Chen, Xiong Chen, Lina Hu, Lifen Xie, Xiao Qiu, Xi Wang, Yuhong Lin, , Ruijun Tian
This study uses phosphotyrosine proteomics to analyze CAR-T cells from patients and donors, finding heightened tyrosine phosphorylation and tonic signaling linked to therapeutic efficacy.
bioRxiv · Dec 22, 2024 · PreprintImmunology