Wentao Li

Large-scale AI-guided discovery of antifreeze peptides reveals functional tandem-repeat architectures

This study uses AI to discover antifreeze peptides, finding that tandem-repeat sequences are functional and effective in inhibiting ice recrystallization.

Programming Biomolecular Interactions with All-Atom Generative Model

This paper introduces AnewOmni, a generative model that designs biomolecules across scales by learning interaction patterns and physical constraints from 5 million complexes.

Learning the All-Atom Equilibrium Distribution of Biomolecular Interactions at Scale

AnewSampling is a generative model that accurately samples all-atom equilibrium distributions of biomolecular interactions, outperforming prior methods and enabling efficient exploration of conformational landscapes.

Purine nucleobases enhance CD8+ T cell effector function

This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.

Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy

This study uses phosphotyrosine proteomics to analyze CAR-T cells from patients and donors, finding heightened tyrosine phosphorylation and tonic signaling linked to therapeutic efficacy.

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

This paper develops a cold-protective treatment for traumatic optic neuropathy using a clinically relevant animal model, showing that combined hypothermia and cold protection reduces inflammation and metabolic stress without cellular damage.