Sierra M. Collins

Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARs

Helix predicts A-to-I RNA editing by ADARs with high accuracy using a structure-aware transformer model, enabling efficient gRNA design for therapeutic applications.

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

This study identifies how histone modifications regulate gene expression in memory and exhausted CD8 T cells, revealing distinct epigenetic programs between these cell types.

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.