Translational regulation of non-autonomous mitochondrial stress response promotes longevity
Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di Chen
The paper identifies translational repression of CYC-2.1 in the germline as a mechanism that extends lifespan through non-autonomous activation of UPRmt and AMPK in C. elegans.
Cell Reports · Jul 1, 2019Peer-reviewedDevelopmental Biology