Di Chen

This study investigates the role of GTBP-1 in heat stress response in C. elegans germline, showing its involvement in stress granule formation and reproductive homeostasis.

This study shows that mutations in H3K9me1/2 methyltransferase genes synergistically extend lifespan in C. elegans daf-2 mutants, enhancing stress resistance through DAF-16 activation.

The paper identifies translational repression of CYC-2.1 in the germline as a mechanism that extends lifespan through non-autonomous activation of UPRmt and AMPK in C. elegans.

The paper constructs a germline-specific RNAi tool in C. elegans by combining an rde-1 mutation with a germline-specific transgene, demonstrating its efficiency and specificity in RNAi knockdown.