SPINK1-COL18A1 Crosstalk Shapes Epigenome and Drives Cancer Stemness in Pancreatic Ductal Adenocarcinoma
Haoyu Tang, Bethsebie Sailo, Xingbo Shang, Md Shahadat Hossan, Jeremy D. Kratz, Paromita Das, Ankit Chhoda, Paulomi Aldo, He Liu, Marie E. Robert, Saryn Doucette, Timothy J. Paris, John W. Kunstman, Emmanouil Pappou, Laura DeLong Wood, , Nita Ahuja
This study identifies SPINK1 as a regulator of epigenomic states and stemness in PDAC through its interaction with COL18A1 and endostatin release.
Cell Reports · Aug 18, 2026Peer-reviewedCancer Biology