Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming
Ping Ren, Shao‐Yu Fang, 赵姝姝, Hanbing Cao, Kaiyuan Tang, Xingbo Shang, Cole W. Christopher, Yunfei Jiao, Medha Majety, Andre Levchenko, David B. Weiner, Sidi Chen, Xiaoyu Zhou
This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.
bioRxiv · Oct 2, 2026 · PreprintImmunology