Author

Lindsie Martin

University of Oklahoma

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

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Chhandosee GangulyiD· 1 shared Leonard M. ThomasiD· 1 shared Rakhi RajaniD· 1 shared Swarmistha Devi AribamiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiochemistry

Chhandosee GangulyORCID

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1 paper

Recent·Most cited

Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation

Chhandosee Ganguly, Lindsie Martin, Swarmistha Devi Aribam, Leonard M. Thomas, Rakhi Rajan

This study investigates how the bridge helix (BH) of Cas12a regulates R-loop formation and RuvC activation through conformational changes, revealing structural mechanisms for improving Cas12a specificity.

bioRxiv · Jan 9, 2025 · PreprintBiochemistry