Author

Leonard M. Thomas

University of OklahomaORCID 0000-0003-3920-0619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Chhandosee GangulyiD· 1 shared David M. DinhiD· 1 shared Elizabeth A. KarriD· 1 shared Lindsie Martin· 1 shared Michael J. McInerneyiD· 1 shared Neil Q. Wofford· 1 shared Rakhi RajaniD· 1 shared Selena YaghoubiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

Chhandosee GangulyORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 13, 2026

Structural Determinants of Catalytic Bias in an AMP-Forming Acetyl-CoA Synthetase from Syntrophus aciditrophicus

Selena Yaghoubi, David M. Dinh, Leonard M. Thomas…·Elizabeth A. Karr

This study identifies structural determinants of catalytic bias in SaAcs1, showing that residues G196 and T197 in the CoA-binding loop influence the preference for AMP formation.

DOI 10.64898/2026.07.06.736832

bacteria (other)structural biology

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BiochemistrybioRxivPreprintJan 9, 2025

Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation

Chhandosee Ganguly, Lindsie Martin, Swarmistha Devi Aribam…·Rakhi Rajan

This study investigates how the bridge helix (BH) of Cas12a regulates R-loop formation and RuvC activation through conformational changes, revealing structural mechanisms for improving Cas12a specificity.

DOI 10.1101/2025.01.09.632262

structural biologyexperimental assay

𝕏 PostBluesky