Competitive catabolism in systemic metabolic homeostasis
Daniel Weilandt, Won Dong Lee, Michael Robert MacArthur, Lingfan Liang, Corey D. Holman, Qingwei Chu, Alexis J. Cowan, Joseph A. Baur, Ned S. Wingreen, Joshua D. Rabinowitz
This study develops a multi-nutrient differential equation model to show how competitive catabolism between glucose, fatty acids, and ketones under fasting conditions leads to systemic metabolic homeostasis, with implications for obesity-induced diabetes.
bioRxiv · Oct 29, 2025 · PreprintPhysiology