Alexis J. Cowan

This study develops a multi-nutrient differential equation model to show how competitive catabolism between glucose, fatty acids, and ketones under fasting conditions leads to systemic metabolic homeostasis, with implications for obesity-induced diabetes.

The paper introduces NetID, a global network optimization method for annotating untargeted metabolomics data, identifying novel metabolites in yeast and mouse datasets.

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.