Structural basis for aphidicolin inhibition of human processive DNA synthesis
Ammar Usman Danazumi, Muhammad Tehseen, Lingyun Zhao, Saleh Alshehri, Vlad‐Stefan Raducanu, Samir M. Hamdan, Alfredo De Biasio
This study reveals the structural mechanism of aphidicolin inhibition of human DNA polymerases Pol δ and Pol ε, showing how it blocks DNA synthesis by altering the polymerase conformation.
bioRxiv · Oct 19, 2026 · PreprintBiophysics