Ammar Usman Danazumi

This study reveals the structural mechanism of aphidicolin inhibition of human DNA polymerases Pol δ and Pol ε, showing how it blocks DNA synthesis by altering the polymerase conformation.

This study presents cryo-EM structures of human DNA replication complexes to elucidate the structural basis of nick translation during Okazaki fragment maturation.

This study presents a cryo-EM structure of the human CTF18-RFC complex bound to PCNA, revealing structural features important for PCNA loading and Pol ε-mediated leading strand synthesis.

This study uses cryo-EM to visualize the dynamics of DNA unwinding by the SV40 Large Tumor Antigen helicase, revealing how ATP hydrolysis drives translocation and strand separation.