Author

Vlad‐Stefan Raducanu

King Abdullah University of Science and TechnologyORCID 0000-0001-6722-9262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

Muhammad TehseeniD· 3 shared Samir M. HamdaniD· 3 shared Alfredo De BiasioiD· 2 shared Ammar Usman DanazumiiD· 2 shared Byungju KimiD· 1 shared Gayun BuiD· 1 shared Inas A ZeiniD· 1 shared Jinseob Lee· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

Muhammad TehseenORCID

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Author profile →

3 papers

Recent·Most cited

Structural basis for aphidicolin inhibition of human processive DNA synthesis

Ammar Usman Danazumi, Muhammad Tehseen, Lingyun Zhao, Saleh Alshehri, Vlad‐Stefan Raducanu, Samir M. Hamdan, Alfredo De Biasio

This study reveals the structural mechanism of aphidicolin inhibition of human DNA polymerases Pol δ and Pol ε, showing how it blocks DNA synthesis by altering the polymerase conformation.

bioRxiv · Oct 19, 2026 · PreprintBiophysics

Structural basis of nick translation in human DNA replication

Inas A Zein, Ammar Usman Danazumi, Muhammad Tehseen, Lingyun Zhao, Kerry Blair, Rania Almaghrabi, Vlad‐Stefan Raducanu, Samir M. Hamdan, Alfredo De Biasio

This study presents cryo-EM structures of human DNA replication complexes to elucidate the structural basis of nick translation during Okazaki fragment maturation.

bioRxiv · Jul 22, 2026 · PreprintBiophysics

smDeepFLUOR: Single-Molecule Deep Learning Fluorescence Classification

Jinseob Lee, Byungju Kim, Gayun Bu, Muhammad Tehseen, Vlad‐Stefan Raducanu, Samir M. Hamdan, Jong‐Bong Lee

smDeepFLUOR uses deep learning to classify single-molecule fluorescence signals, distinguishing specific from nonspecific protein binding with 97% accuracy and capturing DNA synthesis kinetics.

Nature Communications · Jun 21, 2026Peer-reviewedBiophysics