PARP1-mediated 5' flap dynamics facilitate Okazaki fragment maturation
Guojun Shi, Yixing Wang, Yao Yan, Kejiao Li, Lingzhi Ma, Yi Lei, Yingying Wang, Nancy Manriquez, Mian Zhou, Shan Zha, Li Zheng, Binghui Shen
This study identifies context-dependent roles of PARP1 in regulating Okazaki fragment maturation by controlling 5' flap dynamics and DNA ligation processes.
bioRxiv · Apr 30, 2026 · PreprintMolecular Biology