Author

Yixing Wang

City Of Hope National Medical CenterORCID 0000-0003-1852-7700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Binghui SheniD· 3 shared Guojun ShiiD· 3 shared Kejiao Li· 3 shared Yao Yan· 3 shared Yi LeiiD· 3 shared Yingying WangiD· 3 shared Li ZhengiD· 2 shared Mian ZhouiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

Binghui ShenORCID

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3 papers

Recent·Most cited

Cell BiologyNucleic Acids ResearchPeer-reviewedMay 20, 2026

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation

Kejiao Li, Feng Yang, Yingying Wang…·Binghui Shen

This paper shows that XPF degrades 3' flaps in human cells when FEN1 is deficient, enabling Okazaki fragment maturation and preventing DNA damage.

1 citation

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Molecular BiologybioRxivPreprintApr 30, 2026

PARP1-mediated 5' flap dynamics facilitate Okazaki fragment maturation

Guojun Shi, Yixing Wang, Yao Yan…·Binghui Shen

This study identifies context-dependent roles of PARP1 in regulating Okazaki fragment maturation by controlling 5' flap dynamics and DNA ligation processes.

DOI 10.64898/2026.04.27.721142

experimental assay

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Cell BiologybioRxivPreprintOct 6, 2025

JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3

Yao Yan, Guojun Shi, Kejiao Li…·Binghui Shen

2 citations

humanDNA methylation

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