Yao Yan

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation

This paper shows that XPF degrades 3' flaps in human cells when FEN1 is deficient, enabling Okazaki fragment maturation and preventing DNA damage.

PARP1-mediated 5' flap dynamics facilitate Okazaki fragment maturation

This study identifies context-dependent roles of PARP1 in regulating Okazaki fragment maturation by controlling 5' flap dynamics and DNA ligation processes.

DNA replication errors drive genome-wide small inverted triplication dynamics

The paper identifies DNA replication errors as a source of small inverted triplication (SIT) structural variants in yeast, showing their formation mechanism and characteristics.

JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3

Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in S. cerevisiae

This study uses an artificial gene drive system in budding yeast to show that appending nuclear localization signals to Cas9 can modulate nuclease activity and act as a molecular safeguard.

Development of a multi-locus CRISPR gene drive system in budding yeast

This paper develops a multi-locus CRISPR gene drive system in budding yeast that can propagate multiple gene drives using a single Cas9 and three guide RNAs.