A CARF-HAD phosphatase effector provides immunity during the type III-A CRISPR-Cas response
Gianna Stella, Linzhi Ye, Sean F. Brady, Luciano A. Marraffini
This study identifies Chp as a CARF-HAD phosphatase effector that mediates immunity during the type III-A CRISPR-Cas response by inducing growth arrest and depleting ATP and IMP.
Nucleic Acids Research · Nov 26, 2025Peer-reviewedMicrobiology