Author

Gianna Stella

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-9968-1982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

Luciano A. MarraffiniiD· 2 shared Dinshaw J. PateliD· 1 shared Héloïse Carion· 1 shared Linzhi Ye· 1 shared Puja MajumderiD· 1 shared Sean F. BradyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

Luciano A. MarraffiniORCID

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2 papers

Recent·Most cited

A lipid fenestration-gated membrane depolarization mechanism expands the repertoire of CRISPR-mediated anti-phage defense strategies

Puja Majumder, Héloïse Carion, Gianna Stella, Dinshaw J. Patel, Luciano A. Marraffini

The paper identifies a lipid-gated mechanism in CRISPR-Cas systems that uses membrane depolarization to block viral replication.

bioRxiv · Aug 6, 2026 · PreprintMicrobiology

A CARF-HAD phosphatase effector provides immunity during the type III-A CRISPR-Cas response

Gianna Stella, Linzhi Ye, Sean F. Brady, Luciano A. Marraffini

This study identifies Chp as a CARF-HAD phosphatase effector that mediates immunity during the type III-A CRISPR-Cas response by inducing growth arrest and depleting ATP and IMP.

Nucleic Acids Research · Nov 26, 2025Peer-reviewedMicrobiology