Sean F. Brady

Brig3, a DNA glycosylase from a soil metagenome, excises 5-hydroxymethylcytosine from T-even phage DNA; the glucose hydrolase BapA extends defense to glucosylated genomes such as wild-type T4.

This study identifies Chp as a CARF-HAD phosphatase effector that mediates immunity during the type III-A CRISPR-Cas response by inducing growth arrest and depleting ATP and IMP.

This study identifies oxydifficidin as a potent antibiotic against Neisseria gonorrhoeae, effective against drug-resistant strains, due to DedA-mediated uptake and sensitivity to ribosomal protein RplL.