The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming
Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Étienne Blanc, Olivier Molendi‐Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, , Jean‐Sébastien Annicotte
This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.
iScience · Jun 30, 2023Peer-reviewedGenomics