Author

Arnaud Carrier

Centre National de la Recherche ScientifiqueORCID 0000-0002-9200-7685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alexandre PelletieriD· 3 shared Amélie BonnefondiD· 3 shared Fabien DelahayeiD· 3 shared Ana Raquel Melo de FariasiD· 2 shared Bruna Soares LandeiraiD· 2 shared Jean‐Charles LambertiD· 2 shared Johanna Gadaut· 2 shared Marcos R. CostaiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Alexandre PelletierORCID

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Author profile →

4 papers

Recent·Most cited

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma, Soumyabrata Guha, Roger-Junior Eloiflin, Adeline Augereau, Pierre Le Hars, Moritz Schüssler, Yasmine Messaoud-Nacer, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A. Disyak, Clara Taffoni, Robin Charpentier, , Nadine Laguette

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

Nature Communications · Nov 7, 2025Peer-reviewedImmunology

The Alzheimer's disease risk gene BIN1 modulates neural network activity via the regulation of L-type calcium channel expression in human-induced neurons

Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier, Dolores Siedlecki‐Wullich, Johanna Gadaut, Bruna Soares Landeira, Arnaud Carrier, Anaïs-Camille Vreulx, Karine Guyot, Amélie Bonnefond, Philippe Amouyel, Claudio Marcos Queiroz, Devrim Kilinc, Fabien Delahaye, Jean‐Charles Lambert, Marcos R. Costa

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

bioRxiv · Jan 18, 2022 · PreprintNeuroscience

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, , Pierre Dourlen

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

Acta Neuropathologica Communications · Jan 8, 2022Peer-reviewedNeuroscience

Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescence

Alexandre Pelletier, Arnaud Carrier, Yong Mei Zhao, Mickaël Canouil, Mehdi Derhourhi, Emmanuelle Durand, Lionel Berberian, John M. Greally, Francine Hughes, Philippe Froguel, Amélie Bonnefond, Fabien Delahaye

The paper links DNA methylation changes in HSCs from large for gestational age neonates to altered quiescence via transcriptional network disruption.

bioRxiv · Oct 22, 2021 · PreprintGenomics