Author

Lisa Dreolini

Canada's Michael Smith Genome Sciences Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:long-read sequencing· 2 Research Focus:variant calling· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Robert A. HoltiD· 3 shared Scott D. BrowniD· 3 shared Agata Minor· 1 shared Amanda Carlson· 1 shared Amanda Lieu· 1 shared Cody A Despins· 1 shared James W. RoundiD· 1 shared Jessica F. Wilson· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBioinformatics

Robert A. HoltORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A De Novo Algorithm for Allele Reconstruction from Oxford Nanopore Amplicon Reads, with Application to CYP2D6

Scott D. Brown, Lisa Dreolini, Agata Minor, Michelle Mozel, Nancy Wong, Sharon Mar, Amanda Lieu, Maimun Khan, Amanda Carlson, Monica Anne Hrynchak, Robert A. Holt, Perseus I. Missirlis

This paper introduces a de novo algorithm to reconstruct allele sequences from Oxford Nanopore amplicon reads, demonstrating its application to CYP2D6 and HLA with high accuracy.

Bioinformatics · Jul 18, 2026Peer-reviewedBioinformatics

Self-multimerization of mRNA LNP-derived antigen improves antibody responses

Cody A Despins, James W. Round, Lisa Dreolini, Tracy S. Lee, Scott D. Brown, Robert A. Holt

This study compares multimerization domains in mRNA LNP vaccines, finding that IMX313 enhances antibody responses more than other domains.

Vaccines · Jan 12, 2026Peer-reviewedImmunology

Complete sequence verification of plasmid DNA using the Oxford Nanopore Technologies' MinION device

Scott D. Brown, Lisa Dreolini, Jessica F. Wilson, Miruna Balasundaram, Robert A. Holt

The paper describes a cost-effective and accurate plasmid sequencing method using the MinION device, achieving 100% accuracy in consensus sequences and detecting small mutations.

bioRxiv · Jun 21, 2022 · PreprintBioinformatics