Author

Lisa M. Hochrein

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Niles A. PierceiD· 2 shared Jining HuangiD· 1 shared Maayan SchwarzkopfiD· 1 shared Mikhail H. Hanewich-HollatziD· 1 shared Tianjia Jessie GeiD· 1 shared Zhewei CheniD· 1 shared

Activity by Year

2018-2019 · peak 1/yr

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6 top collaborators · 9 mutual co-author links

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2 shared papersSynthetic Biology

Niles A. PierceORCID

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2 papers

Recent·Most cited

Synthetic BiologyACS Central SciencePeer-reviewedJun 4, 2019

Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacteria via Dynamic RNA Nanotechnology

Mikhail H. Hanewich-Hollatz, Zhewei Chen, Lisa M. Hochrein…·Niles A. Pierce

This paper introduces conditional guide RNAs (cgRNAs) that control CRISPR/Cas activity via RNA triggers, enabling programmable gene regulation in E. coli with varying dynamic ranges and crosstalk levels.

111 citationstop 3%

E. coliCRISPR screen

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedDec 7, 2018

Signal Transduction in Human Cell Lysate via Dynamic RNA Nanotechnology

Lisa M. Hochrein, Tianjia Jessie Ge, Maayan Schwarzkopf, Niles A. Pierce

The paper demonstrates scRNAs that perform conditional RNA interference in human cell lysate, showing programmable signal transduction between mRNAs X and Y with a 20-fold response difference.

16 citations

humanscRNA-seq

𝕏 PostBluesky