Author

Lisa M. Linares

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander W. CharneyiD· 3 shared Brendan Sullivan· 3 shared Brian Harris KopelliD· 3 shared Emily MoyaiD· 3 shared Eric E. SchadtiD· 3 shared Eric VornholtiD· 3 shared Esther ChengiD· 3 shared Girish N. NadkarniiD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Alexander W. CharneyORCID

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3 papers

Recent·Most cited

A study of gene expression in the living human brain

Lora E. Liharska, You Jeong Park, Kimia Ziafat, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Ryan C. Thompson, Eric Vornholt, Brendan Sullivan, Vanessa V. Cohen, Prashant Kota, Claudia Feng, Esther Cheng, Jessica Johnson, Marysia-Kolbe Rieder, , Alexander W. Charney

This study compares gene expression in living and postmortem human brain tissue, finding significant differences that challenge the assumption that postmortem data accurately represents living brain gene expression.

Molecular Psychiatry · Aug 23, 2025Peer-reviewedGenetic & Genomic Medicine

Divergent landscapes of A-to-I editing in postmortem and living human brain

Miguel Rodríguez de los Santos, Brian Harris Kopell, Ariela Buxbaum Grice, Gauri Ganesh, Andy Yang, Pardis Amini, Lora E. Liharska, Eric Vornholt, John F. Fullard, Pengfei Dong, Eric Y. H. Park, Sarah Zipkowitz, Deepak A. Kaji, Ryan C. Thompson, Donjing Liu, , Michael S. Breen

This study compares A-to-I RNA editing in postmortem and living human brain tissues, revealing significant differences in editing levels and their association with cellular processes and neurological conditions.

Nature Communications · Jun 26, 2024Peer-reviewedGenetic & Genomic Medicine

Characterizing cell type specific transcriptional differences between the living and postmortem human brain.

Eric Vornholt, Lora E. Liharska, Esther Cheng, Alice Hashemi, You Jeong Park, Kimia Ziafat, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Ryan C. Thompson, Brendan Sullivan, Emily Moya, Girish N. Nadkarni, Robert Sebra, Eric E. Schadt, , Noam D. Beckmann

The paper compares gene expression differences between living and postmortem human brain samples using snRNA-seq and develops a model to account for these differences in analysis.

medRxiv · May 1, 2024 · PreprintGenetic & Genomic Medicine