Brian Harris Kopell

Toward A Whole-Brain Interface Enabled by High-Resolution Surface Electrophysiology

This paper presents a functional atlas of the human central nervous system using high-resolution surface electrophysiology from 70 patients, revealing conserved electrophysiological patterns and enabling neuroprosthetic applications.

Single neurons in the human substantia nigra encode social learning signals

The paper records single neuron activity in the substantia nigra during social learning tasks and finds dopaminergic neurons encode norm prediction error valence more strongly during human vs computer interactions.

Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex

This paper shows that dopamine and serotonin changes during deep brain stimulation predict symptom relief in treatment-resistant depression.

Longitudinal Changes in Cortical Response Dynamics with Deep Brain Stimulation to the Subcallosal Cingulate for Treatment-Resistant Depression

This study tracks changes in cortical response dynamics during SCC-DBS for treatment-resistant depression, finding reduced latency and increased magnitude of stimulation-evoked potentials over time.

A study of gene expression in the living human brain

This study compares gene expression in living and postmortem human brain tissue, finding significant differences that challenge the assumption that postmortem data accurately represents living brain gene expression.

Divergent landscapes of A-to-I editing in postmortem and living human brain

This study compares A-to-I RNA editing in postmortem and living human brain tissues, revealing significant differences in editing levels and their association with cellular processes and neurological conditions.

Human Substantia Nigra Neurons Encode Reward Expectations

This study shows human substantia nigra neurons encode reward expectations through firing rates modulated by trial outcomes and linked to reaction times.

Characterizing cell type specific transcriptional differences between the living and postmortem human brain.

The paper compares gene expression differences between living and postmortem human brain samples using snRNA-seq and develops a model to account for these differences in analysis.

Genetics of the human microglia regulome refines Alzheimer's disease risk loci

The paper identifies regulatory mechanisms for 21 Alzheimer's disease risk loci in human microglia using transcriptome and chromatin accessibility profiling.

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinsons disease are associated with LRRC37A/2 expression in astrocytes

The paper identifies three H1 sub-haplotypes at the 17q21.31 locus associated with Parkinson's disease risk and links them to LRRC37A/2 expression in astrocytes.