Macrophage inhibitor clodronate enhances liver transduction of lentiviral but not AAV vectors or mRNA lipid nanoparticles in vivo.
Loukia Touramanidou, Sonam Gurung, Andrei Claudiu Cozmescu, Dany P.B. Perocheau, DALE A. MOULDING, Deborah A. Ridout, Alex Cavedon, Summar Siddiqui, Lisa M. Rice, Patrick F. Finn, Paolo G.V. Martini, Andrea Frassetto, Simon N. Waddington, John Robert Counsell, Paul Gissen, Julien Baruteau
This study shows that clodronate liposomes enhance lentiviral liver transduction but not AAV or LNP-mRNA in mice.
bioRxiv · Jul 26, 2023 · PreprintMolecular Biology