Sonam Gurung

This paper demonstrates the use of AAV9 vectors to deliver AntagoNATs targeting a natural antisense transcript in a DS mouse model, improving survival and reducing seizures.

This study shows that clodronate liposomes enhance lentiviral liver transduction but not AAV or LNP-mRNA in mice.

This study shows that mRNA therapy restores ureagenesis and glutathione metabolism in ASL-deficient mice, correcting liver disease and neurocognitive impairments.

This study shows that activating autophagy via Beclin-1 improves biochemical and clinical outcomes in two types of urea cycle disorders.

The paper shows that suppression of synaptic activity reduces ADAR2 levels, leading to decreased GluK2 Q/R editing and increased KAR surface expression.

This study shows that ADAR2-mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors through activity-dependent changes in ADAR2 proteostasis.