Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis
Georgia Gunner, Himanish Basu, Yong Lu, Matthew Bergstresser, Liwei Sun, Dylan V. Neel, So Yoen Choi, Isaac M. Chiu
This study shows GSDMD is activated in ALS mice but its loss does not improve disease outcomes or reduce neuroinflammation.
Neurobiology of Disease · Aug 5, 2025Peer-reviewedNeuroscience