Author

Georgia Gunner

Harvard UniversityORCID 0000-0002-6734-9632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Ana BadimoniD· 2 shared Anne SchaeferiD· 2 shared Dorothy P. SchaferiD· 2 shared Dylan V. NeeliD· 2 shared Himanish BasuiD· 2 shared Isaac M. ChiuiD· 2 shared Matthew BergstresseriD· 2 shared Pinar AyataiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Ana BadimonORCID

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Author profile →

4 papers

Recent·Most cited

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling

Travis E. Faust, Yi‐Han Lee, Ciara D. O’Connor, Margaret A. Boyle, Georgia Gunner, Violeta Durán‐Laforet, Loris L. Ferrari, Robert E. Murphy, Ana Badimon, Kristina Sakers, Çağla Eroğlu, Pinar Ayata, Anne Schaefer, Dorothy P. Schafer

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

Cell · Sep 1, 2025Peer-reviewedNeuroscience

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis

Georgia Gunner, Himanish Basu, Yong Lu, Matthew Bergstresser, Liwei Sun, Dylan V. Neel, So Yoen Choi, Isaac M. Chiu

This study shows GSDMD is activated in ALS mice but its loss does not improve disease outcomes or reduce neuroinflammation.

Neurobiology of Disease · Aug 5, 2025Peer-reviewedNeuroscience

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

Dylan V. Neel, Himanish Basu, Georgia Gunner, Matthew Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Michelle Evelyn Watts, Christine Marques, Aaron Held, Brian J. Wainger, , Isaac M. Chiu

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

Neuron · Mar 13, 2023Peer-reviewedNeuroscience

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, M. Aurel Nagy, Liwang Liu, Shane M. Bemiller, Ki-Wook Kim, Sérgio A. Lira, Bruce T. Lamb, Andrew R. Tapper, Richard M. Ransohoff, Michael E. Greenberg, , Dorothy P. Schafer

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.

Nature Neuroscience · Jun 17, 2019Peer-reviewedNeuroscience