Himanish Basu

This study shows GSDMD is activated in ALS mice but its loss does not improve disease outcomes or reduce neuroinflammation.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.

This study shows that disrupting the ANK3 gene in mice affects microtubule dynamics via GSK3/CRMP2 signaling, linking it to psychiatric illness mechanisms.