Targeting fibroblast activation suppresses chemotherapy-induced pro-invasive remodeling of the extracellular matrix
Anna Yui, Liyi Peng, Katie C. Lew, Dylan Landau, Crystal Zhang, Thomas J. Gerton, Marissa Li, Steffy Jullian-Guyard, Mallory Caron, Jackson P. Fatherree, Rachel A. McGinn, Abraham L. Bayer, Pilar Alcaide, Charlotte Kuperwasser, Madeleine Julie Oudin
This study shows that chemotherapy activates fibroblasts in TNBC, promoting pro-invasive ECM production, and that nintedanib can suppress this effect.
bioRxiv · Sep 8, 2026 · PreprintCancer Biology