Charlotte Kuperwasser

This study shows immune cells influence stem-cell niche formation and organoid development through TGF-β signaling in a 3D breast organoid model.

This study shows that chemotherapy activates fibroblasts in TNBC, promoting pro-invasive ECM production, and that nintedanib can suppress this effect.

This study shows that environmental chemical mixtures disrupt mammary development and induce epigenetic changes linked to breast cancer, particularly invasive lobular carcinoma.

This paper introduces a breast organoid model that captures tissue organogenesis with high-resolution live imaging, revealing novel morphogenesis processes and stromal generation.

This study shows TNBC cells activate sensory neurons via TRPV1, driving nerve outgrowth and tumor progression, with TRPV1 knockout reducing tumor growth and metastasis.

This study shows DDR1 regulates RUNX1-CBFβ to drive breast stem cell differentiation into multiple lineages and tissue structures.

This study generates 3D mammary organoids from eight eutherian mammals and a marsupial, revealing species-specific roles of ROCK in branching morphogenesis.