Lizbeth Enriquez Najera

This study shows that methylglyoxal-induced glycation stress causes aortic stiffening through oxidative stress and cellular senescence, and a glycation-lowering compound mitigates these effects.

This study shows that growth hormone excess in mice causes liver aging by increasing glycation stress, which can be reversed with glycation-lowering compounds.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.