Inhibition of Hsp70 suppresses neuronal hyperexcitability and attenuates seizures by enhancing A-type potassium currents
Fang Hu, Jingheng Zhou, Yanxin Lu, Lizhao Guan, Ningning Wei, Zhuo Huang, Yi‐Quan Tang, KeWei Wang
This study shows that inhibiting Hsp70 reduces neuronal hyperexcitability and seizures by boosting A-type potassium currents through the degradation of Kv4-KChIP4a complexes.
bioRxiv · Jan 30, 2018 · PreprintNeuroscience