Zhuo Huang

The paper identifies an inhibitory domain in AtKC1 that stabilizes the closed conformation of AKT1, preventing its activation, and shows a stoichiometry change in a mutant form.

The paper identifies a functional coupling between Slack and NaV1.6 that enhances quinidine blockade of Slack, suggesting a new approach for treating KCNT1-related epilepsy.

The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.

This paper characterizes a Scn2a gene trap knockout mouse model with reduced Nav1.2 expression, showing behavioral and physiological abnormalities associated with Scn2a deficiency.

This study shows that inhibiting Hsp70 reduces neuronal hyperexcitability and seizures by boosting A-type potassium currents through the degradation of Kv4-KChIP4a complexes.