Remifentanil self-administration promotes circuit- and sex-specific adaptations within the prefrontal-accumbens pathways
Saurabh S. Kokane, Shalana I. Atwell, Aric Madayag, Eden M. Anderson, Skyler Demis, Annabel Engelhardt, Logan Friedrich, Matthew C. Hearing
This study investigates sex- and pathway-specific synaptic adaptations in mPFC-NAc circuits following remifentanil self-administration and abstinence, revealing differences in AMPA/NMDA ratios and presynaptic signaling.
Frontiers in Cellular Neuroscience · May 8, 2026Peer-reviewedNeuroscience