Matthew C. Hearing

This study investigates sex- and pathway-specific synaptic adaptations in mPFC-NAc circuits following remifentanil self-administration and abstinence, revealing differences in AMPA/NMDA ratios and presynaptic signaling.

This study shows that aversive stimuli reduce nucleus accumbens dopamine and increase drug taking and escape behavior in rats, suggesting a common physiological mechanism for both adaptive and maladaptive responses.

This study shows that adolescent morphine exposure impairs cognitive flexibility in female mice but not males, with effects persisting into adulthood for flexibility but not discriminative learning.

This study examines sex-specific changes in motivated behavior and mesoaccumbal dopamine subcircuit plasticity during protracted morphine withdrawal in mice, finding male-specific reductions in non-drug reward motivation linked to lateral DA subcircuit alterations.

This study shows that GIRK channel signaling in male mice is critical for prelimbic cortical function and stress-induced cognitive flexibility, but not in females.

This study investigates the role of parvalbumin interneuron GIRK signaling in affect and cognition in male and female mice, finding sex-specific effects on behavior and neuronal firing.

This study identifies sex-specific synaptic changes in the prefrontal cortex that underlie opioid-induced cognitive impairment and suggests sex-based interventions for addiction treatment.

This study investigates morphine-induced changes in glutamate transmission in nucleus accumbens neurons, identifying distinct plasticity patterns in D1- and D2-MSNs associated with reward, reinstatement, and withdrawal.

This study shows that chronic unpredictable stress causes distinct plasticity in D1 and D2 pyramidal neurons in the prefrontal cortex, affecting their excitability and synaptic transmission.