Annabel Engelhardt

Remifentanil self-administration promotes circuit- and sex-specific adaptations within the prefrontal-accumbens pathways

This study investigates sex- and pathway-specific synaptic adaptations in mPFC-NAc circuits following remifentanil self-administration and abstinence, revealing differences in AMPA/NMDA ratios and presynaptic signaling.

Adolescent morphine exposure impairs cognitive flexibility in female but not male mice.

This study shows that adolescent morphine exposure impairs cognitive flexibility in female mice but not males, with effects persisting into adulthood for flexibility but not discriminative learning.

Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility

This study shows that GIRK channel signaling in male mice is critical for prelimbic cortical function and stress-induced cognitive flexibility, but not in females.

The role of parvalbumin interneuron GIRK signaling in regulation of affect and cognition inmale and female mice

This study investigates the role of parvalbumin interneuron GIRK signaling in affect and cognition in male and female mice, finding sex-specific effects on behavior and neuronal firing.

Sex-specific prefrontal cortex dysfunction underlying opioid-induced cognitive impairment

This study identifies sex-specific synaptic changes in the prefrontal cortex that underlie opioid-induced cognitive impairment and suggests sex-based interventions for addiction treatment.