Calcium-Driven Activation of Gelsolin: Mechanism and the Active-State Ensemble
Bruno Stegani, Loic Girois, Federico Ballabio, Toni Giorgino A, Riccardo Capelli, Guillaume Gerbaud, Michela Bollati, Mario Milani, Alessio Bonucci, Carlo Camilloni, Matteo de Rosa
This study elucidates the mechanism of gelsolin activation through a combination of experimental and computational methods, revealing a dynamic, domain-dependent process leading to a heterogeneous active-state ensemble.
bioRxiv · Oct 22, 2026 · PreprintBiophysics