Federico Ballabio

This study elucidates the mechanism of gelsolin activation through a combination of experimental and computational methods, revealing a dynamic, domain-dependent process leading to a heterogeneous active-state ensemble.

This study uses constant-pH simulations to show that β2AR inactivation is linked to protonation events and sodium ion interactions, challenging existing models of GPCR function.

The paper identifies a missense mutation in HvCHLI causing reduced chlorophyll content in barley, which shows potential for breeding crops adapted to arid conditions.

This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.

This study uses in silico methods to investigate the role of calcium in the inactivation of the human olfactory receptor OR51E2, identifying a novel mechanism involving divalent ion coordination.