Neuronal compartmentalization results in impoverished axonal mitochondria
Adrián Martí Pastor, Liam S.C. Lewis, Stephan Müller, Pedro Guedes-Dias, Lorena Olifiers, Polina Pelkonen, Almudena del Rio Martin, Caroline Fecher, Nikolai P. Skiba, Ying Hao, Antoneta Gavoci, Laura Trovò, Mehmet Akif Aktas, Hariharan Murali Mahadevan, Angelika Bettina Harbauer, , Thomas Misgeld
The paper uses proteomics to compare mitochondrial diversity in somatodendritic and axonal compartments across neurons, finding axonal mitochondria are 'impoverished' with reduced mtDNA expression and impaired oxidative phosphorylation.
bioRxiv · Oct 27, 2025 · PreprintNeuroscience