Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons
Hariharan Murali Mahadevan, Ayat E. Rehailia, Adrián Martí Pastor, Isabel M.C. Geelhaar, Luciano Román-Albasini, Regina Feederle, Monika S. Brill, Thomas Misgeld, Angelika Bettina Harbauer
The paper identifies mitochondrial transport of MAPT mRNA via SYNJ2a/SYNJ2BP complex and shows its role in maintaining Tau levels and axonal growth in glutamatergic neurons.
bioRxiv · Jan 10, 2026 · PreprintNeuroscience