Laura Trovò

The paper uses proteomics to compare mitochondrial diversity in somatodendritic and axonal compartments across neurons, finding axonal mitochondria are 'impoverished' with reduced mtDNA expression and impaired oxidative phosphorylation.

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.

This study shows that higher glutathione levels in the nucleus accumbens predict better sustained performance in reward-incentivized effort tasks and that manipulating GSH levels affects motivation.